Transport induced LLPS in protein condensates

Raw data and plotting script for a submitted manuscript titled "Active Transport as a Mechanism of Microphase Selection in Biomolecular Condensates". In this work, we introduce a physical mechanism by which motor-driven transport along cytoskeletal filaments can arrest coarsening in phase-separating biomolecular condensates. Using analytical theory and three-dimensional numerical simulations, we show that stochastic binding and release of proteins to rapidly moving motors generates an effective long-range repulsion, shifting the spinodal and stabilizing finite-sized droplets at a tunable length scale.

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Publication 1
Title of related publication
Active Transport as a Mechanism for Microphase Selection in Biomolecular Condensates
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DFG projects 465145163 (CRC 1552); 248882694; 464588647 (CRC 1551).
Computer resources NHR South-West at JGU Mainz
Responsible Person's Name (PI) Prof. Dr. Friederike Schmid
Responsible Person's Email friederike.schmid@uni-mainz.de
Responsible Person's Affiliation Institute for Physics, Johannes Gutenberg University Mainz, Germany